Concomitant use of some medicines may also increase the risk of muscle damage. The risk of myopathy is greater in: elderly patients (>65 years) women patients with renal impairment or hypothyroidism patients who consume large quantities of alcohol those with a history of previous muscle problems during treatment with statins or other lipid-lowering drugs or those with family history of muscle disorders. However, its most serious form, rhabdomyolysis, is a very rare side effect. Myopathy is a known side effect of all statins, including simvastatin, and the risk increases with higher doses. An estimated 11 patients in the simvastatin 80-mg group developed rhabdomyolysis compared with none in the simvastatin 20-mg group (for some suspected rhabdomyolysis cases there were no detailed data to confirm 100% diagnosis according to the criteria used).įor interim details of SEARCH, see: SEARCH Study Collaborative Group. However, myopathy occurred in 52 patients (0♹%) randomly assigned simvastatin 80 mg compared with one patient (0♰2%) randomly assigned simvastatin 20 mg. drugs (statins): Your doctor may prescribe this class of medication if you. There was no evidence of increased total or cause-specific mortality, vascular mortality, non-vascular mortality, or higher risk of cancer or haemorrhagic stroke with the high dose of simvastatin. Rare side effects include seizures and problems controlling internal body. The incidence of MVEs was similar for 80 mg (1477, 24♵%) versus 20 mg (1553, 25♷% risk ratio 0♹4 ). Simvastatin must be taken in the exact dose as ordered by a doctor as side effects of the drug are mostly caused by changes in the dosage. Simvastatin may also be used to prevent certain types of heart. This medicine may help prevent medical problems (eg, heart or blood vessel problems, heart attacks, or strokes) caused by clogged blood vessels. The results showed that treatment with simvastatin 80 mg did not provide any significant benefits over simvastatin 20 mg. Simvastatin comes as an oral tablet that should be taken once a day, usually in the evening, in average daily dose of 5 to 80 mg. Simvastatin is used together with a proper diet to treat high cholesterol and triglyceride (fat) levels in the blood. SEARCH was a multicentre, double-blind, active-treatment, factorial-design study conducted at 88 sites in the UK, which evaluated the effect of treatment with Zocor 80 mg versus 20 mg on major vascular events (MVEs, defined as fatal coronary events, non-fatal myocardial infarction, coronary revascularisation procedure, non-fatal or fatal stroke, or peripheral revascularisation procedure) in 12 064 patients with a history of myocardial infarction, over a median follow-up of 6♷ years. This update follows a review of the Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH). In this prospective, randomized, open-label, blinded end-point evaluation trial, patients were randomly assigned to receive a high dose of atorvastatin (80 mg/day n 4439), or an usual dose of simvastatin (20 mg/day, titrated up to 40 mg/day if necessary n 4449). The drug may damage the liver, being the reason for liver tests before and during the use of simvastatin. There is a possibility for some allergic reactions to simvastatin, too. Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine data These can interact with statins and lead to serious problems. Patients using simvastatin are likely to experience headache, nausea and vomiting, stomack pain, diarrhea, and sometimes muscle pain. Similar changes are being implemented to the product information for combination products that contain simvastatin, such as Inegy (simvastatin combined with ezetimibe). Cyclobenzaprine and tramadol erowid.The simvastatin (Zocor) product information (Summary of Product Characteristics and Patient Information Leaflet) has been updated to include warnings about increased risk of myopathy in patients receiving the highest licensed dose (80 mg). Side effects it may cause headaches it may cause constipation - to prevent this, drink plenty of water or juice, and eat more dietary fibre it may cause.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |